Two sample MR report
ZNF506_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0398544 | 0.3012982 | 0.9031396 |
| Weighted median | 5 | -0.0413178 | 0.0199418 | 0.0382730 |
| Inverse variance weighted | 5 | -0.0448112 | 0.0157774 | 0.0045082 |
| Simple mode | 5 | -0.0413366 | 0.0251811 | 0.1760227 |
| Weighted mode | 5 | -0.0415058 | 0.0249377 | 0.1713686 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5312225 | 3 | 0.9119803 |
| Inverse variance weighted | 0.5314939 | 4 | 0.9703635 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0053856 | 0.3269147 | 0.9878905 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.05e-05 | 0 | TRUE | 0.5005888 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
